Equine Mobility Support - 40 Ounces (1134 Grams) (E8000)


Equine Mobility Support - 40 Ounces (1134 Grams) (E8000)

Equine Mobility Support by Standard Process 40 Ounces (1134 Grams) ($71.00).

Equine joints inevitably suffer stress during daily riding, training, and competing. Friction and load-bearing stress on a horse's joints ultimately affect comfort and performance, sometimes even ...

40 Ounces (1134 Grams)
(Id #E8000)
$71.00   Out of Stock

Equine Mobility Support by Standard Process 40 Ounces (1134 Grams) ($71.00).


Equine Mobility SupportDescription

Equine joints inevitably suffer stress during daily riding, training, and competing. Friction and load-bearing stress on a horse's joints ultimately affect comfort and performance, sometimes even before the signs are apparent.

Equine Mobility Support is a scientifically researched formula that can help:

  • Promote healthy joint function, flexibility, and mobility
  • Supplies antioxidants to help protect against damage from free radicals
  • Supports a healthy inflammatory response and full and firm stride*

Key Ingredients

Glucosamine

Glucosamine is an important component of cartilage growth, maintenance, and repair. While research is ongoing in horses, meta-analysis of human clinical trials has confirmed the value of glucosamine in support of bone health1,2,3. In the horse, glucosamine has been implicated in regulation of matrix metalloproteinase expression, an important enzyme working in joint tissue.4, 5

In practice, glucosamine is commonly used to support healthy joints, much the same way that glucosamine is used in humans.

Chondroitin Sulfate

Chondroitin sulfate is an important component of the extracellular matrix of connective tissue. Low-molecular-weight chondroitin sulfate is bioavailable in the horse, although to a limited degree.6 While the mechanism of chondroitin sulfate action in joint health remains to be determined, it is an important component of compounds found in various functional components of the joint.

Wheat Germ Oil

Wheat germ oil provides a rich source of vitamin E. Vitamin E promotes healthy circulation, enhances athletic performance, and helps reduce muscle cramping. Vitamin E is an important lipophilic antioxidant implicated in a number of physiological functions. Tocopherols support immune function and lessen the inflammatory response by scavenging reactive oxygen species.

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Flaxseeds

Flax Meal

Flax contains significant levels of omega-3 fatty acids, specifically alpha linolenic acid (ALA) and omega-3 fatty acids, which have been implicated in reducing the inflammatory response. Studies have shown that omega-3 fatty acids reduced inflammatory thromboxane and decreased endotoxin-induced TNF production in horses.7, 8

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Ginger Root

Ginger

Ginger contains a broad spectrum of bioactive compounds. Several ginger compounds have well-documented effects on the inflammatory response. For example, 6-gingerol and 6-paradol have such activity, while 8-paradol and 9-shagaol have been shown to inhibit COX-2 activity. This action may explain ginger's historic uses.9,10

This ingredient could be considered a controlled substance by certain entities that govern equine competitions. We advise those who feed any supplement to competing horses to check with the governing body specific to the even regarding whether the product contains ingredients that could be considered a controlled substance.


Educational Tools


Clinical Evaluations

Equine Metabolic Support in a 4-Month Evaluation

Equine Metabolic Support Mobility Study

 

First Trial: 8-Week Evaluation of Lameness

Horses representing different breeds, ages, and gender were evaluated prior to initiating the study to define their lameness. Animals having a spavin score of greater than 1 in a leg joint were recruited. Fifteen horses were enrolled in the study and were given ¼ cup (approximately 2 ounces) of Equine Mobility Support daily for 60 days. Equine participants were re-evaluated at 30-day intervals. Change in spavin score, or lack thereof, was noted after 30 and 60 days. Serum chemistry and complete blood cell counts were performed prior to and during the study to assure no unexpected side effects developed during the study.

With one exception, all horses showed improvement of aggregate spavin score (total for all limbs) by 30 days. At 60 days, all horses showed continued improvement. In addition, there were no actionable changes in blood chemistries. Subjective comments from the trainers involved indicated many animals showed greater range of motion.

Second Trial

Eighteen additional animals were recruited for assessment. These animals were more active (dressage, endurance, jumping, therapy) and likely to exhibit different stress symptoms/indicators on their limbs. Sixteen animals finished the 60-day trial with a similar protocol. The two animals withdrawn from the study were not fed the supplement during the time the owners were on vacation. The results support those found in the initial trial.

These studies contained no control group and represent the observations and measurements by the attending veterinarian.

References

  1. Clegg DO, Reda DJ, Harris CL, et. al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006; 354:795-808.
  2. McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA. 2000; 283:1469-1475.
  3. Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells G. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev: CD002946; 2005.
  4. Neil KM, Orth MW, Coussens PM, Chan PS, Caron JP. Effects of glucosamine and chondroitin sulfate on mediators of osteoarthritis in cultured equine chondrocytes stimulated by use of recombinant equine interleukin-1beta. Am J Vet Res. 2005; 66:1861-1869.
  5. Chan PS, Caron JP, Orth MW. Effect of glucosamine and chondroitin sulfate on regulation of gene expression of proteolytic enzymes and their inhibitors in interleukin-1-challenged bovine articular cartilage explants. Am J Vet Res. 2005; 66:1870-1876.
  6. Du J, White N, Eddington ND. The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulfate after oral and intravenous single dose administration in the horse. Biopharm Drug Dispos. 2004; 25:109-116.
  7. McCann ME, Moore JN, Carrick JB, Barton MH. Effect of intravenous infusion of omega-3 and omega-6 lipid emulsions on equine monocyte fatty acid composition and inflammatory mediator production in vitro. Shock. 2000; 14:222-228.
  8. Morris DD, Henry MM, Moore JN, Fischer JK. Effect of dietary alpha-linolenic acid on endotoxin-induced production of tumor necrosis factor by peritoneal macrophages in horses. Am J Vet Res. 1991; 52:528-532.
  9. Surh Y. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat Res. 1999; 428:305-327.
  10. Tjendraputra E, Tran VH, Liu-Brennan D, Roufogalis BD, Duke CC. Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorg Chem. 2001; 29:156-163.