Equine Metabolic Support


Equine Metabolic Support

Equine Metabolic Support by Standard Process 40 Ounces (1134 Grams) ($84.00).

The metabolic system is complex, involving organs such as the thyroid, liver, kidneys, and pancreas. Some signs indicative of metabolic stress may include:Changes in insulin levelsSeasonal pasture sen...

40 Ounces (1134 Grams)
(Id #E7900)
$84.00   Out of Stock

Equine Metabolic Support by Standard Process 40 Ounces (1134 Grams) ($84.00).


Equine Metabolic SupportDescription

The metabolic system is complex, involving organs such as the thyroid, liver, kidneys, and pancreas. Some signs indicative of metabolic stress may include:
  • Changes in insulin levels
  • Seasonal pasture sensitivities
  • Immune system challenges
  • Excess weight or fatty deposits

Equine Metabolic Support:

  • Promotes healthy glucose metabolism and insulin function
  • Provides antioxidants
  • Supports the endocrine system*

Equine Metabolic Support can be used for either short- or long-term support.


Key Ingredients

Licorice root

There is some evidence that licorice root can help maintain glucose homeostasis as well as pituitary hormone homeostasis.1 This is the only ingredient that may directly impact the underlying pituitary imbalance.

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Cinnammon Sticks

Cinnamon

There is some evidence that components of cinnamon can modulate glucose homeostasis.2-13 The rationale for ingredients addressing blood glucose levels is that they are an important consequence of the disease. By maintaining normal glucose levels, it may be possible to bring other endocrine signals back to normal.

Cayenne (chili powder)

As with cinnamon, there is increasing evidence that chili powder can help maintain normal glucose levels. The mechanism is unclear. Ahuja KD et al. (2006) suggest that regular consumption of chili may attenuate postprandial hyperinsulinemia.5,7

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Green tea powder

This ingredient could be considered a controlled substance by certain entities that govern equine competitions. We advise those who feed any supplement to competing horses to check with the governing body specific to the even regarding whether the product contains ingredients that could be considered a controlled substance.

Green tea extract

Contains catechins/polyphenols, which work in a similar fashion as the flavonoids. Additionally, they have a strong antioxidant capacity and directly influence a number of inflammatory pathways.

Chromium

Potentiates insulin actions and combines with several other components to make the glucose tolerance factor.14-20

Vanadium

Can mimic insulin's actions. It is possible that by slowing glucose metabolism, improving blood glucose levels, and mimicking insulin's actions, circulating levels in a horse with metabolic challenges may be reduced.21-28

Buckwheat flour

Buckwheat seed and juice contains a variety of flavonoids including rutin. Flavonoids are found primarily conjugated to sugar molecules. In this form there is some evidence that they can compete with other sugars for uptake into the body. This might effectively slow the absorption of sugar and lessen the postprandial glucose surge. This would lessen the concomitant insulin spike. In addition, rutin has been implicated in the maintenance of capillary integrity and, along with the other flavonoids, acts as an antioxidant.29-34


Clinical Evaluations

Figure: 1

Twenty-nine horses were identified with elevated insulin, which can be associated with challenges to the metabolic system. Four veterinarians participated in the evaluations. The animals were given 1/4 cup (approximately 2 ounces) of Equine Metabolic Support daily for four months.

Results

The response in fasting insulin levels varied, but predominantly decreased (20 animals). Six animals had variable responses and three animals had increased levels. Figure 1 shows the average serum insulin level and corresponding blood glucose levels over the course of the trial for all animals. Even though blood glucose levels rose slightly, they still remained within the normal range for a horse.

References

  1. Boyle SP, Dobson VL, Duthie SJ, et al. Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study. Eur J Clin Nutr 2000;54(10):774-782.
  2. Mathiesen FR. Arterial insufficiency in the leg treated with rutosides. A double blind trial. Vasa 1974;3(3):319-324.
  3. Riabokon' EN, Gavrilenko TI, Kornilina EM, et al. [The effect of Wobenzym on the atherogenic potential and inflammatory factors at the rehabilitation stage for patients who have had a myocardial infarct]. Lik Sprava 2000;(5):111-114.
  4. Ihme N, Kiesewetter H, Jung F, et al. Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled clinical trial. Eur J Clin Pharmacol 1996;50(6):443-447.
  5. Ortolani O, Conti A, De Gaudio AR, et al. Protective effects of N-acetylcysteine and rutin on the lipid peroxidation of the lung epithelium during the adult respiratory distress syndrome. Shock 2000;13(1):14-18.
  6. Mayer B, Schumacher M, Brandstatter H, et al. High-throughput fluorescence screening of antioxidative capacity in human serum. Anal Biochem 2001;297(2):144-153.
  7. Anderson RA. Chromium in the prevention and control of diabetes. Diabetes Metab 2000;26(1):22-27.
  8. Bahijri SM, Mufti AM. Beneficial effects of chromium in people with type 2 diabetes, and urinary chromium response to glucose load as a possible indicator of status. Biol Trace Elem Res 2002;85(2):97-109.
  9. Balk EM, Tatsioni A, Lichtenstein AH, Lau J, Pittas AG. Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials. Diabetes Care. 2007 Aug;30(8):2154-63. Epub 2007 May 22.
  10. Hoeger WW, Harris C, Long EM, Hopkins DR. Four-week supplementation with a natural dietary compound produces favorable changes in body composition. Adv Ther. 1998 Sep-Oct;15(5):305-14.
  11. Jovanovic L, Gutierrez M, Peterson CM. Chromium supplementation for women with gestational diabetes mellitus. J Trace Elem Exp Med 1999;12(2):91-97.
  12. Kleefstra N, Houweling ST, Bakker SJ, et al. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care. 2007 May;30(5):1092-6.
  13. Huss, U., Ringbom, T., Perera, P., Bohlin, L., and Vasange, M. Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. J Nat Prod. 2002;65(11):1517-1521.
  14. Reddy, A. M., Seo, J. H., Ryu, S. Y., Kim, Y. S., Kim, Y. S., Min, K. R., and Kim, Y. Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-kappaB inhibitors from Cinnamomum cassia. Planta Med 2004;70(9):823-827.
  15. Dragland, S., Senoo, H., Wake, K., Holte, K., and Blomhoff, R. Several culinary and medicinal herbs are important sources of dietary antioxidants. J Nutr 2003;133(5):1286-1290.
  16. Shobana, S. and Naidu, K. A. Antioxidant activity of selected Indian spices. Prostaglandins Leukot.Essent.Fatty Acids 2000;62(2):107-110.
  17. Berrio, L. F., Polansky, M. M., and Anderson, R. A. Insulin activity: stimulatory effects of cinnamon and brewer's yeast as influenced by albumin. Horm.Res 1992;37(6):225-229.
  18. Broadhurst, C. L., Polansky, M. M., and Anderson, R. A. Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric.Food Chem 2000;48(3):849-852.
  19. Imparl-Radosevich, J., Deas, S., Polansky, M. M., Baedke, D. A., Ingebritsen, T. S., Anderson, R. A., and Graves, D. J. Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signalling. Horm.Res 1998;50(3):177-182.
  20. Jarvill-Taylor, K. J., Anderson, R. A., and Graves, D. J. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll.Nutr 2001;20(4):327-336.
  21. Kar, A., Choudhary, B. K., and Bandyopadhyay, N. G. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol 2003;84(1):105-108.
  22. Khan, A., Bryden, N. A., Polansky, M. M., and Anderson, R. A. Insulin potentiating factor and chromium content of selected foods and spices. Biol Trace Elem.Res 1990;24(3):183-188.
  23. Kreydiyyeh, S. I., Usta, J., and Copti, R. Effect of cinnamon, clove and some of their constituents on the Na(+)-K(+)-ATPase activity and alanine absorption in the rat jejunum. Food Chem Toxicol 2000;38(9):755-762.
  24. Lee, H. S. Inhibitory activity of Cinnamomum cassia bark-derived component against rat lens aldose reductase. J Pharm Sci 2002;5(3):226-230.
  25. Swanston-Flatt, S. K., Day, C., Bailey, C. J., and Flatt, P. R. Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice. Acta Diabetol.Lat. 1989;26(1):51-55.
  26. Onderoglu, S., Sozer, S., Erbil, K. M., Ortac, R., and Lermioglu, F. The evaluation of long-term effects of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats. J.Pharm.Pharmacol. 1999;51(11):1305-1312.
  27. Vanadium - help for blood sugar problems? Treatment update. 8-1-1999;11(6):5-7.
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  29. Shafrir, E., Spielman, S., Nachliel, I., Khamaisi, M., Bar-On, H., and Ziv, E. Treatment of diabetes with vanadium salts: general overview and amelioration of nutritionally induced diabetes in the Psammomys obesus gerbil. Diabetes Metab Res.Rev. 2001;17(1):55-66
  30. Shao, J., Catalano, P. M., Yamashita, H., Ishizuka, T., and Friedman, J. E. Vanadate enhances but does not normalize glucose transport and insulin receptor phosphorylation in skeletal muscle from obese women with gestational diabetes mellitus. Am.J.Obstet.Gynecol. 2000;183(5):1263-1270.
  31. Shechter, Y. Insulin-mimetic effects of vanadate. Possible implications for future treatment of diabetes. Diabetes 1990;39(1):1-5.
  32. Shechter, Y. and Shisheva, A. Vanadium salts and the future treatment of diabetes. Endeavour 1993;17(1):27-31.
  33. Srivastava, A. K. Anti-diabetic and toxic effects of vanadium compounds. Mol.Cell Biochem. 2000;206(1-2):177-182.
  34. Thompson, K. H. and Orvig, C. Vanadium compounds in the treatment of diabetes. Met.Ions.Biol.Syst. 2004;41:221-252.